Gene
cyb5r4
- ID
- ZDB-GENE-050522-225
- Name
- cytochrome b5 reductase 4
- Symbol
- cyb5r4 Nomenclature History
- Previous Names
-
- ncb5or (1)
- im:4727699
- zgc:112177
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Predicted to be involved in generation of precursor metabolites and energy; oxidation-reduction process; and superoxide metabolic process. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in blood vasculature. Orthologous to human CYB5R4 (cytochrome b5 reductase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Weber et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018506 | Cytochrome b5, heme-binding site |
| Domain | IPR001199 | Cytochrome b5-like heme/steroid binding domain |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR007052 | CS domain |
| Domain | IPR008333 | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Domain | IPR037908 | Cytochrome b5 reductase 4, p23 domain |
| Family | IPR001834 | NADH:cytochrome b5 reductase-like |
| Family | IPR051872 | Cytochrome b5/Flavoprotein Reductase |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR036400 | Cytochrome b5-like heme/steroid binding domain superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Length | CS domain | Cytochrome b5/Flavoprotein Reductase | Cytochrome b5, heme-binding site | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain superfamily | Cytochrome b5 reductase 4, p23 domain | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | HSP20-like chaperone | NADH:cytochrome b5 reductase-like | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BKQ7
|
577 | |||||||||||||
|
UniProtKB:Q502I6
|
527 | |||||||||||||
|
UniProtKB:A0A8M2BKQ3
|
312 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyb5r4-201
(1)
|
Ensembl | 2,656 nt | ||
| mRNA |
cyb5r4-202
(1)
|
Ensembl | 1,548 nt |
Interactions and Pathways
No data available
Plasmids
No data available